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May 1950

URINARY EXCRETION OF GLUCURONIC AND SALICYLIC ACIDS IN NORMAL AND IN RHEUMATIC CHILDREN

Author Affiliations

CHICAGO
From La Rabida Jackson Park Sanitarium, Stritch School of Medicine of Loyola University and the University of Illinois College of Medicine.

Am J Dis Child. 1950;79(5):826-837. doi:10.1001/archpedi.1950.04040010843005
Abstract

A STUDY of the excretion of glucuronic (also glycuronic) acid in the urine is generally connected with the study of the excretion of substances with a phenolic or alcoholic structure which are conjugated with glucuronic acid in the liver.

This study, however, was undertaken for the following reason. It is generally recognized that the pathologic manifestations of the primary lesion in rheumatic fever are found in the collagenous connective tissues of the body. The connective tissues have within them "mucoid" which contains glucuronic acid1 and hyaluronic acid, a mucopolysaccharide composed of glucosamine and glucuronic acid in a proportion of 1: 1.2 It was, therefore, thought that children with rheumatic fever might manifest some specific disturbance of glucuronic acid metabolism which could be detected by examination of the urine with and without the administration of acetylsalicylic acid, a compound which in part becomes conjugated with glucuronic acid. If this

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