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May 1950

BRONCHIAL CHANGES IN EXPERIMENTALLY INDUCED CYSTIC DEGENERATION OF THE PANCREAS

Author Affiliations

BUDAPEST, HUNGARY
From the First Department of Pediatrics and the Institute for Experimental Medicine of the Hungarian Petrus Pázmány University.

Am J Dis Child. 1950;79(5):846-854. doi:10.1001/archpedi.1950.04040010863007
Abstract

IN A RECENT report on the induction of cyst formation and consequent fibrosis in the pancreas1 it was said that in the lungs various changes, such as hemorrhages and emphysema, occurred but squamous metaplasia or other bronchial changes were absent. Since the presentation of that study, several new series of similar experiments have been carried out and their results, together with those seen on reexamination of the original preparations, revealed data that made us revise this previous statement, especially since bronchial changes were also observed in animals in which the pancreatic lesion was provoked by deficient diets.

MATERIAL AND METHODS  Seventy-one male albino rats, ranging in weight from 160 to 190 Gm. were used.Thirty-five animals were fed a well balanced stock diet with a liberal supplement of water-soluble vitamins and cod liver oil with added vitamin A. The amount of neither food nor water was restricted. Carbon tetrachloride,

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