IN 1944, Doan1 described a blood dyscrasia which in his opinion was caused by a malfunctioning spleen. He pointed out certain similarities among this so-called panhematopenia, congenital hemolytic anemia and primary thrombopenic purpura. He postulated that in primary splenic panhematopenia the spleen does not exercise selectivity for any particular element of the blood in its pathologic destructive tendency, but that it destroys all of them at an excessive rate. Recently, Doan and Wright2 discussed this subject in more detail. In contrast to Doan's opinion, Dameshek3 expressed his feeling that the overactive spleen inhibits the bone marrow, possibly by hormonal control. Both authors emphasized the reality of the syndrome and pointed out the benefits of splenectomy in selected cases. Because of the paucity of reports of this syndrome descriptions of 2 cases are presented.
REPORT OF CASES
Case 1.—B. S., a white girl 11 years of age, was
WILLIAMS ML, KELSEY WM. SPLENIC PANHEMATOPENIA IN CHILDREN. Am J Dis Child. 1950;79(5):862-867. doi:10.1001/archpedi.1950.04040010879009