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July 1950

ANOXIA AS A CAUSE OF FETAL DEATH AND CONGENITAL DEFECT IN THE MOUSE

Author Affiliations

BOSTON
From the Department of Epidemiology, Harvard School of Public Health.

Am J Dis Child. 1950;80(1):34-45. doi:10.1001/archpedi.1950.04040020041004
Abstract

THAT anoxia at critical stages of prenatal development is an important cause of acquired malformations of the fetus is an inference derived from earlier studies of mongolism, retrolental fibroplasia and tracheoesophageal fistula.1 This hypothesis has been tested experimentally by submitting pregnant mice at various stages of gestation to rarefied atmospheres.

MATERIALS AND METHODS  The white mouse is a prolific, easily handled mammal in which the onset of pregnancy can be determined with much certainty by means of an inspissated plug appearing in the vagina shortly after copulation. Females used were chosen at random from a laboratory strain maintained for the past four years with avoidance of brother and sister mating. Fertility has remained satisfactory, with a mean of 8.2 normal pups per litter. For the purposes of these experiments the day on which the copulation plug appears is regarded as the first day of pregnancy, and it is our

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