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July 1950

LARVAL ASCARIASIS AS A CAUSE OF CHRONIC EOSINOPHILIA WITH VISCERAL MANIFESTATIONS

Author Affiliations

CLEVELAND
From the Departments of Pediatrics, Pathology and Microbiology, Western Reserve University.

Am J Dis Child. 1950;80(1):46-58. doi:10.1001/archpedi.1950.04040020053005
Abstract

A SYNDROME has recently been described1 which is characterized by chronic eosinophilia and eosinophilic granulomatous lesions of the liver associated with fever, leukocytosis, hyperglobulinemia and pulmonary changes. This syndrome has been related to the group of disorders characterized by eosinophilia and pulmonary changes which include Löffler's syndrome2 and tropical eosinophilia.3

The etiologic basis of this syndrome has not been proved, but it has been assumed to represent an allergic response to unknown antigens with the liver acting as a "shock organ."lb In one report the antigen is assumed to be a toxin from the helminth Ascaris lumbricoides.1a

A patient with the aforementioned clinical entity in whom the basic etiologic mechanism could be clearly demonstrated was recently studied in this clinic. The hepatic lesions were found to be caused by the presence within that organ of the larvae of A. lumbricoides. This patient's case is presented

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