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For those physicians who are particularly interested in the action of synthetic analgesic drugs, this publication by the New York Academy of Sciences is extremely appropriate. Since the relief of pain is one of the first duties of all physicians, this review of the analgesic drugs should be readily available to each of them.
Among the new findings brought out by this symposium is the fact that meperidine (demerol®) hydrochloride is of no value in the treatment of biliary colic, since it has a decided constrictive effect on the sphincter of Oddi and will increase pain from the biliary tract by its spasmogenic action.
The new synthetic drug methadone hydrochloride has probably only a limited value as an analgesic and at present has its chief use in the oral treatment of pain in patients with cancer for whom its cheapness and effectiveness may cause it eventually to succeed metopon hydrochloride,
Symposium on Newer Synthetic Analgesics.. Am J Dis Child. 1950;80(3):528–529. doi:10.1001/archpedi.1950.04040020539019