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October 1950

RESPIRATORY ACIDOSIS IN CHILDREN WITH CEREBRAL, PULMONARY AND CARDIOVASCULAR DISORDERS

Author Affiliations

BALTIMORE; BUFFALO
From the Children's Hospital and the Department of Pediatrics, University of Buffalo School of Medicine.

AMA Am J Dis Child. 1950;80(4):578-599. doi:10.1001/archpedi.1950.04040020590006
Abstract

ALTHOUGH there have been numerous communications on the more commonly found metabolic disturbances of acid-base balance, as well as on respiratory alkalosis, reports of cases of respiratory acidosis have been meager in the pediatric literature.1 However, with a specific search among patients who might be predisposed to it, not infrequently instances of respiratory acidosis may be found. It is the purpose of this report to describe 16 cases of this entity observed at the Children's Hospital of Buffalo and to call attention to the important fact that unless it is suspected and correctly diagnosed incorrect therapy may ensue.

Uniformity of concentration and reaction of body fluids is controlled largely by renal function with the exception of the plasma carbon dioxide content, which is controlled mainly by the respiratory mechanisms.2 The normal pH of the blood must be maintained within the narrow limits of 7.35 to 7.45 in order

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