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Case Reports
November 1950

CONGENITAL LYMPHATIC LEUKEMIA

Author Affiliations

MILWAUKEE
From the laboratory of the Milwaukee Hospital.

AMA Am J Dis Child. 1950;80(5):800-802. doi:10.1001/archpedi.1950.04040020814008
Abstract

Leukemia occurring in infancy is quite uncommon. The clinical manifestations are the same as those in the adult, except for the acute fulminating course which the disease always runs. Cross1 in 1944 was able to collect 23 cases of congenital leukemia from a survey of the literature. Only 3 of these were of the lymphatic variety. Kelsey and Andersen2 in 1939 reviewed the literature on leukemia occurring in the neonatal period. They were of the opinion that the following criteria should be present before one can call an early developing leukemia a "congenital leukemia." Clinically, the symptoms should present themselves either at birth or within a few days after birth. There should be hepatomegaly, splenomegaly and enlarged lymph nodes. The peripheral blood should show leukocytosis with the presence of immature cells. The history should be free of any indication of syphilis, icterus gravis neonatorum or erythroblastosis. Histologically, there

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