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January 1913


Author Affiliations

From the Children's Medical Department, Massachusetts General Hospital.

Am J Dis Child. 1913;V(1):25-32. doi:10.1001/archpedi.1913.04100250028003

Various methods have been employed in the estimation of kidney function. These methods may be divided roughly into (1) a study of the excretion of normal constituents of the urine, principally water, sodium chlorid and urea; (2) the determination of the freezing point of urine as compared with body fluids; (3) a study of the excretion of certain substances not normally found in the urine, introduced into the body for the specific purpose of the investigation of their elimination by the kidney. These substances include iodin, methylene-blue, phloridzin, indigo-carmin and numerous other drugs. One might also mention in this connection a further method of study by ligature of the vessels of the kidney. Investigations have been conducted on kidneys whose action was supposed to be normal and on kidneys known to be pathologic. The chief interest has centered in the pathologic conditions, for it is with the diseased kidney that

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