The pyelitis of infancy, which is a fairly common disease, is generally understood by pediatricians, as expressed in their writings, as a disease characterized by an active, remitting temperature, and which is treated most successfully by the use of alkalies, while some cases may be cured by hexamethylenamin in doses of ½ to 2 grains three times a day, or every three hours.
Recent experiences have led me to believe that such statements should be materially modified. We should rather say that the pyelitis of infancy is a disease which is usually characterized by a high remitting temperature, but may give rise to no temperature, and that while some patients may be cured safely by neutralization of the urine with alkalies and others by doses of hexamethylenamin such as those named, that the most efficient treatment in difficult cases is by the use of very large doses of hexamethylenamin aided
FREEMAN RG. THE DIAGNOSIS AND TREATMENT OF PYELITIS IN INFANCY. Am J Dis Child. 1913;VI(2):117-121. doi:10.1001/archpedi.1913.04100320054007