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November 1913

THE COMPLEMENT FIXATION REACTION OF THE BLOOD OF CHILDREN AND INFANTS, USING THE BACILLUS ABORTUS AS ANTIGEN

Author Affiliations

MINNEAPOLIS

Am J Dis Child. 1913;VI(5):326-333. doi:10.1001/archpedi.1913.04100350039003
Abstract

The passage of substances through the intestinal wall, and the effect of the ingestion of biologically active bodies on the reactions in the blood and other tissues has been a subject of much interest to many, and especially so to pediatrists. We hope to throw some light on this problem by the demonstration of the fact that a specific reaction can be obtained in the blood of a considerable number of children.

The specific reaction in question is that of the complement fixation test, using the bacillus of infectious abortion of cattle as an antigen. The significance of this particular reaction becomes apparent when we consider that epidemic abortion is common among cattle; that the presence of the Bacillus abortus can be demonstrated in cow's milk, and that the reaction is seemingly specific.

The discussion concerning the enteral absorption of homologous or heterologous proteins has been, and still is, of

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