Since the year 1820 when Nasse of the University of Bonn formulated the law that males alone are the bleeders, and the disease, hemophilia, is transmitted by normal females through their marriage with normal males, much has been written on the subject of hemophilia. This disease, which Grandidier termed "The most hereditary of hereditary diseases," has been discussed from all angles and points of view, and the only conclusion that has been reached is that the coagulation of the blood was defective (Wright, Addis, et al.).
What the cause of this delayed coagulation is has been explained in various ways. Sahli and Morawitz have stated that the calcium content of the blood is normal in this disease; that the thrombogen content of the blood is normal; and they ascribe the delayed coagulation to a deficiency in the thrombokinase (the activator of the thrombogen) of the blood. This theory has been
KAHN M. METABOLISM STUDIES IN HEMOPHILIA. Am J Dis Child. 1916;XI(2):103-111. doi:10.1001/archpedi.1916.04110080020003