As a part of general study of the urine of normal children under different dietetic conditions, a number of urines were studied to determine whether or not ketones and betahydroxybutyric acid were present, and if so, in what quantities. Although discussions of acidosis in childhood, and particularly of pathological conditions in which large amounts of "acetone bodies" appear in the urine are numerous, there are no figures in literature, so far as we know, in regard to the amount of these substances in the urine of "normal" or healthy children.
The method used for determining their presence was that of Shaffer, in which the acetone and the aceto-acetic acid are first distilled over, and then the betahydroxybutyric acid oxidized by potassium bichromate and distilled over as acetone. The amount of acetone is then determined by the iodimetric method of Messinger. The children from whom the twenty-four-hour specimens examined were obtained
VEEDER BS, JOHNSTON MR. ON THE PRESENCE OF KETONES AND BETAHYDROXYBUTYRIC ACID IN THE URINE OF NORMAL CHILDREN. Am J Dis Child. 1916;XI(4):291-293. doi:10.1001/archpedi.1916.04110100052006