The fact seems established, through the investigations of many workers,1 that in the adult, fasting involves an increase in the excretion of creatin. As far as we are aware, this condition has not been identified in the young. Fasting, however, affects the creatin output differently in different species of animals, for while in the adult of the human species, an increase in this component is observed, the reverse is the case in starving dogs.2 McCollum and Steenbock3 find the pig refractory under the influence of starvation.
Mellanby4 reported a case of cyclic vomiting (recurrent vomiting) in a boy of 6 in which marked loss in weight occurred during the attacks. He speaks of creatin excretion in a child of 6 as being an abnormality and says also that there was an increase in creatin excretion two and three days before the attack, during which and after
CUTTER IS, MORSE M. STUDIES IN THE METABOLISM OF CHILDRENII. CREATIN RETENTION IN MARASMUS. Am J Dis Child. 1916;XI(5):331–332. doi:10.1001/archpedi.1916.04110110024003