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July 1916

A STUDY OF THE ETIOLOGY OF CHOREA

Author Affiliations

Professor of Pediatrics, Harvard Medical School; Visiting Physician, Children's Hospital; and Consulting Physician, Infants' Hospital and the Floating Hospital, Boston; Instructor in Bacteriology, Harvard Medical School, Boston BOSTON
From the Medical and Bacteriologic Services of the Boston Children's Hospital.

Am J Dis Child. 1916;XII(1):61-72. doi:10.1001/archpedi.1916.04110130064005
Abstract

This study was undertaken primarily to determine, if possible, the parts which syphilis and bacterial infection play in the etiology of chorea. Several other subjects, such as the relative frequency of endocarditis and rheumatism in association with chorea and the frequency with which possible foci of infection, such as diseased tonsils and carious teeth, are present in chorea, have also been incidentally investigated. The spinal fluid has also been studied in a number of instances. Twenty-six children, eleven boys and fifteen girls, were studied, their ages varying between 3 and 11 years. One of the children died of chorea and several had a very severe type of the disease, but the course was mild or moderate in the remainder.

THE RÔLE OF SYPHILIS IN THE ETIOLOGY OF CHOREA  According to Flatau,1 Kowalewsly was the first to call attention to the possible etiologic relation of syphilis to chorea. It was

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