The value of a reliable yet practicable method for the determination of the coagulation time of blood is obvious, yet the amount of experimental work expended on it within recent years testifies to the difficulties inherent to most of the clinical methods which have been devised.
The large majority of observations, however, have been made on adults, so that it seems desirable to extend the study to infants and children, both in health and disease, in order to decide, if possible, on a standard for comparison.
Before presenting the conclusions of other authors and the results of our own work, we may consider briefly the various coagulometers in use, with an equally brief discussion of the most important and established factors of error more or less inherent to any clinical method.
A recent article by Myer Solis-Cohen contains such a thorough consideration of instruments and methods that it would appear
CARPENTER HC, GITTINGS JC. THE COAGULATION TIME OF BLOOD IN INFANTS AND CHILDREN. Am J Dis Child. 1913;V(1):1-17. doi:10.1001/archpedi.1913.04100250004001