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Article
July 1922

BILATERAL HYPOPLASTIC CYSTIC KIDNEYSREPORT OF A CASE SIMULATING CHRONIC DIFFUSE NEPHRITIS IN A GIRL THREE YEARS OF AGE

Author Affiliations

ROCHESTER, MINN.
From the Department of Pediatrics and the Pathologic Laboratory, Johns Hopkins University, and the Harriet Lane Home of the Johns Hopkins Hospital.

Am J Dis Child. 1922;24(1):1-19. doi:10.1001/archpedi.1922.04120070004001
Abstract

Functional insufficiency of the kidney in early infancy produces characteristic clinical findings. These are best seen in cases of congenital chronic nephritis.1 Children so affected show great developmental disturbances dating from early life, if not from birth. Associated with the developmental disturbance are stunting and backwardness in growth, difficulty in feeding, anemia and rachitis. More direct evidence of renal insufficiency is given by the excretion of a large volume of dilute urine with a low specific gravity. This urine contains a slight amount of albumin, and casts are present in small numbers. In those cases in which it has been determined, the phenolsulphonepththalein excretion is low. Death usually results from uremia. The pathologic picture in these cases is similar to, if not identical with, that seen in the chronic diffuse nephritis of adults.

The clinical findings in such cases, however, are determined by the functional rather than by the

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