Rapidly as the advance in blood transfusion has taken place, and brilliant as the results have been, it must be admitted that some details have been more or less neglected.
A study of the literature shows that one of the simplest questions still remains unanswered, viz., the exact amount of blood to be transfused. It is very important that this be determined in every case as exactly as is possible; because if too much is given, danger of hypertransfusion becomes imminent; if too little is given, the result will be nil.
Until now no method has been known by means of which one could determine beforehand how much blood was needed to cause a definite increase in the number of red blood cells. Nor could one foretell the degree of increase after the transfusion of a known quantity of normal blood. In fact, the question of blood dosage is a
HALBERTSMA T. THE AMOUNT OF BLOOD TO BE TRANSFUSED IN ANEMIA OF CHILDREN (BLOOD DOSAGE). Am J Dis Child. 1922;24(4):269-272. doi:10.1001/archpedi.1922.04120100002001