Comparatively few observations are recorded on the meningeal irritability in animals. Auer1 observed the functional effect of intraspinal injections of serums with and without preservatives in dogs and in monkeys. Flexner and Amoss2 reported that the intraspinal injection of serum of a normal horse brings profound changes in the meningeal mechanism of the monkey.
It is evident that the substances, introduced into the subarachnoid spaces, act as foreign bodies, and, if sterile, give rise to aseptic inflammation.
The object of this investigation is to study the meningeal irritability in animals, when several substances have been introduced in the subarachnoid space. All the experiments were carried out in adult rabbits. As an index of the severity of the meningeal irritation in the rabbit, we examined the number of cells per cubic millimeter of its spinal fluid.
THE CELLULAR CONSTITUENTS OF THE NORMAL SPINAL FLUID IN THE RABBIT
KASAHARA M. EXPERIMENTAL STUDY IN MENINGEAL IRRITABILITY. Am J Dis Child. 1924;28(4):407-414. doi:10.1001/archpedi.1924.04120220003001