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Article
December 1924

FURTHER CLINICAL INVESTIGATIONS INTO THE DISEASES ARISING IN CONSEQUENCE OF A DEFICIENCY IN THE FAT-SOLUBLE A FACTOR

Author Affiliations

COPENHAGEN, DENMARK
From the Children's Department of Rigshospitalet, University of Copenhagen.

Am J Dis Child. 1924;28(6):659-667. doi:10.1001/archpedi.1924.04120240002001
Abstract

My description of the diseases occurring in children from a deficiency in the fat-soluble A factor was quickly acknowledged by those physiologists who were working at vitamin problems. This was due to the close parallel, which in many respects exists between the disease I have observed in children and the condition that can be produced in young rats, by keeping them for a long time on a diet poor in the fat-soluble A factor but otherwise adequate. With clinicians it was a different matter. Although nearly a decade has passed since I published my first contributions on this subject, there are still many clinicians, especially in Germany, who have never appreciated the fact that the absence of the fat-soluble A factor gives rise to a well defined disease just as, for example, the absence of the C factor does. There are, however, many German authors who trace a connection between

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