In 1934 DeLange1 reported a syndrome, occurring in infants, characterized by congenital muscular hypertrophy, extrapyramidal disturbances and mental deficiency. She described three cases which had come directly under her observation and cited one case which had been reported nearly a half-century before by Bruck.2 With the possible exception of one other case, which will be referred to later (Schiff and Balint3), these four cases are the only instances of this syndrome which we have found reported in the literature. We are presenting an additional case, with certain studies on the metabolism of the patient.
REPORT OF CASE
History.—A Negro boy was delivered at the Philadelphia General Hospital spontaneously and without injury at term in July 1933. The mother, a low grade moron, was only 14 years of age. The father of the patient was also the father of the child's mother. The weight of the child
HALL BE, SUNDERMAN FW, GITTINGS JC. CONGENITAL MUSCULAR HYPERTROPHY. Am J Dis Child. 1936;52(4):773-783. doi:10.1001/archpedi.1936.04140040003001