In the course of a single month, March 1939, my associates and I had the opportunity to observe 3 children with severe acute hemolytic anemia of unknown origin. The symptoms and the course of the illness resembled those of Lederer's anemia.
The disease first described by Lederer1 in 1925 as "a form of acute hemolytic anemia, probably of infectious origin" is now commonly called Lederer's anemia as in the article by Holst.2 About 70 cases, mostly those of children, have been reported from different countries.
The course of the illness is highly dramatic. The onset is sudden. In a few days or even hours, during which severe vomiting is the most striking symptom, a serious state arises which is hard to interpret. The skin is pale gray or yellowish, the eyes are sunken and dull and consciousness becomes clouded. The urine is brown or rust red; examination of
ROBINSON P. FAVISM IN CHILDREN. Am J Dis Child. 1941;62(4):701–707. doi:10.1001/archpedi.1941.02000160002001