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April 1943


Am J Dis Child. 1943;65(4):519-522. doi:10.1001/archpedi.1943.02010160003001

Since the introduction of fluid diphtheria toxoid and alum-precipitated toxoid for the immunization against diphtheria, both local and constitutional reactions following their use have been observed. There are many reports in the literature describing the types of reactions following the administration of alum-precipitated toxoid, but few reports have been published of reactions following the administration of fluid formaldehyde-treated toxoid. Difficulties are encountered in the recording of reactions following administration of toxoid. Observers do not agree on the definition of either local or constitutional reactions or on the degree of the severity of reactions. The number of reactions will naturally vary according to the interpretation. Some observers designate mere redness at the point of inoculation as a reaction. Others do not consider local reactions to be present unless the area of redness is extensive or there is pain interfering with the ordinary function of the arm. In many instances there is