November 1944


Author Affiliations

From the Medical Service of Glenn Dale Sanatorium.

Am J Dis Child. 1944;68(5):301-307. doi:10.1001/archpedi.1944.02020110002001

REVIEW OF THE LITERATURE  A condition in which there is marked total leukocytosis with high relative lymphocytosis and without clinical signs or symptoms has so far as we know been reported in the literature only 4 times previously. Three of these reports were of children, while 1 was of an adult.In February 1941, Reyersbach and Lenert1 reported under the title "Infectious Mononucleosis Without Clinical Signs or Symptoms" 16 cases occurring in a sanatorium for children who had had rheumatic fever. They were thought to be atypical cases of infectious mononucleosis, although they did not have any of its characteristics except lymphocytosis. The ages of the children varied from 6½ to 12 years. The leukocyte counts ranged from 18,400 to 59,300, with from 71 to 93 per cent of the cells lymphocytes. The Paul-Bunnell test, which is based on the fact that blood serum of patients with infectious mononucleosis