June 06, 2011

Poliovirus Vaccines: Past, Present, and Future

Author Affiliations

Author Affiliations: Office of Global Health Programs and Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia (Dr Nathanson); and Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia (Dr Kew).


Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2011

Arch Pediatr Adolesc Med. 2011;165(6):489-490. doi:10.1001/archpediatrics.2011.77

An important pediatric advance of the 1950s was the introduction of inactivated poliovirus vaccine (IPV), also known as the Salk vaccine.1 Inactivated poliovirus vaccine and its counterpart, oral poliovirus vaccine (OPV), also known as the Sabin vaccine,2 have saved hundreds of thousands of children and adults from contracting paralytic poliomyelitis, a major scourge of the mid-20th century.3 The celebration of the 100th anniversary of the Archives of Pediatrics and Adolescent Medicine provides a fitting opportunity to describe the effect of poliovirus vaccines during the past 50 years. This topic is particularly pertinent now because a major effort is underway to achieve the global eradication of wild poliovirus47; however, the merits of this quest are being debated within the international health care community.6,810