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An 18-year-old woman presented with a 4-week history of a solitary painful bullous skin lesion over the lower right anterior tibia accompanied by generalized myalgia, polyarthalgia, joint stiffness, paraesthesia, and episodic ankle swelling. The lesion first appeared as a skin-colored papule and, within a week, developed an erythematous halo. Her medical history includes asthma and acne. To our knowledge, there is no family history of this condition. Her medications included minocycline hydrochloride (for 25 months for acne), ranitidine hydrochloride, contraceptive pills, and iron supplements.
Odhav A, Odhav C, Dayal NA. Rare Adverse Effect of Treatment With Minocycline. JAMA Pediatr. 2014;168(3):287-288. doi:10.1001/jamapediatrics.2013.3763