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In Reply We thank Stock and Kemp for their comments on our findings reported in the article “Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study: Outcomes in Children at 5 Years of Age (MACS-5).”1 We do, however, wish to point out that the significant findings related to neurosensory dysfunction (odds ratio, 3.70 [95% CI, 1.57-8.75]; P = .004) were confined to children who were born at term gestation and were subjected to at least 1 additional course of antenatal corticosteroids. The effect was not observed in the children born preterm. Further analysis is being undertaken to evaluate the association between antenatal corticosteroid exposure, gestational age at birth, and outcomes.
Asztalos EV, Willan AR, Matthews SG. More Evidence That Unnecessary Antenatal Treatments Cause Harm–Reply. JAMA Pediatr. 2014;168(4):389-390. doi:10.1001/jamapediatrics.2013.5244