To compare the effectiveness of the use of insulin lispro with the use of regular insulin in managing children with diabetes in outpatient settings.
In this prospective study, telephone records of 75 children treated for ketonuria were analyzed. Outcome was based on the number of successful home treatment episodes (hospitalization not required), the amount of insulin the patients needed, and the time to resolution of ketonuria.
Doses of supplemental insulin used to treat patients with both moderate and large urine ketone values were similar (P>.05) in the insulin lispro and regular insulin groups. Likewise, the time to resolution of moderate or large ketonuria was not statistically different (P>.05) between the 2 groups. No hospitalizations were required for any of the patients for whom management via telephone was attempted.
These data indicate that insulin lispro is an effective option for the outpatient management of ketonuria.
Travaglini MT, Garg SK, Chase HP. Use of Insulin Lispro in the Outpatient Management of Ketonuria. Arch Pediatr Adolesc Med. 1998;152(7):672–675. doi: