Original Article
July 1998

Use of Insulin Lispro in the Outpatient Management of Ketonuria

Author Affiliations

From the Department of Pharmacy, Children's Hospital (Dr Travaglini), the Department of Pediatrics, University of Colorado Health Sciences Center (Drs Garg and Chase), and the Barbara Davis Center for Childhood Diabetes (Dr Chase), Denver, Colo.


Copyright 2003 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2003

Arch Pediatr Adolesc Med. 1998;152(7):672-675. doi:

Objective  To compare the effectiveness of the use of insulin lispro with the use of regular insulin in managing children with diabetes in outpatient settings.

Design  In this prospective study, telephone records of 75 children treated for ketonuria were analyzed. Outcome was based on the number of successful home treatment episodes (hospitalization not required), the amount of insulin the patients needed, and the time to resolution of ketonuria.

Results  Doses of supplemental insulin used to treat patients with both moderate and large urine ketone values were similar (P>.05) in the insulin lispro and regular insulin groups. Likewise, the time to resolution of moderate or large ketonuria was not statistically different (P>.05) between the 2 groups. No hospitalizations were required for any of the patients for whom management via telephone was attempted.

Conclusion  These data indicate that insulin lispro is an effective option for the outpatient management of ketonuria.