The recent article by Donoghue et al1 reports a case of a previously healthy, but enuretic, 10-year-old boy who developed severe hyponatremia (nadir, 117 mmol/L) with resulting convulsions following 3 weeks of nightly 40-µg doses of intranasal desmopressin therapy. What was the weight of their patient? The authors nicely commented on some of the pitfalls of such therapy and reviewed some of the published reports of similar circumstances. Complications likely are underreported.
Schwartz ID. Hyponatremic Seizure in a Child Using Desmopressin for Nocturnal Enuresis. Arch Pediatr Adolesc Med. 1998;152(10):1037-1038. doi: