Oral antacids are occasionally prescribed for infantile colic, gastroesophageal reflux, esophagitis, and other peptic disorders.1 It has long been known that prolonged treatment with nonabsorbable antacids such as aluminum-magnesium hydroxides can limit gastrointestinal absorption of phosphorus.2 Hypophosphatemic bone disease, either rickets or osteomalacia, is a well-known complication of impaired renal tubular resorption of phosphate,3 but is rarely caused by nutritional phosphate deprivation. Although antacid-induced hypophosphatemic osteomalacia has been extensively reported in adults,4- 9 very few reports exist in the pediatric literature.10,11 We report a case of rickets and secondary craniosynostosis in an infant following long-term administration of an aluminum-containing antacid.
Shetty AK, Thomas T, Rao J, Vargas A. Rickets and Secondary Craniosynostosis Associated With Long-term Antacid Use in an Infant. Arch Pediatr Adolesc Med. 1998;152(12):1243-1245. doi:10.1001/archpedi.152.12.1243