Dr Barton's comments in regard to the sample size we used are correct. Because of the small sample size, many of the statistical comparisons may have been susceptible to a type II error. We may have had a larger sample size and detected more differences if we included other patients with adenovirus infection. However, we wanted to use only cases that raised enough suspicion of Kawasaki disease that even an experienced pediatric infectious disease physician had difficulty making the diagnosis. We agree with Dr Barton that age is an important factor to evaluate when considering the diagnosis of Kawasaki disease. A clear description of cobblestoning of the palpebral conjunctiva was not present in the 7 patients with acute adenoviral infection; however, this may be due to lack of documentation rather than to its nonexistence.
Barone SR. Differentiation of Adenoviral Infection and Kawasaki Disease—Reply. Arch Pediatr Adolesc Med. 2001;155(1):97. doi:10.1001/archpedi.155.1.95