[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.168.87. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Commentary
April 2002

Genetic Epidemiology and Congenital MalformationsFrom the Chromosome to the Crib

Author Affiliations

From the Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock.

Arch Pediatr Adolesc Med. 2002;156(4):315-320. doi:10.1001/archpedi.156.4.315

Birth defects or congenital malformations are a significant public health concern that affects 3% to 4% of all live births, and many elective pregnancy terminations or spontaneous abortions. Every year in the United States, approximately 150 000 babies are born with birth defects.1 Birth defects and genetic diseases are the leading causes of infant deaths and result in substantial mortality and morbidity throughout childhood.2 Although birth defects account for 15% to 30% of all pediatric hospitalizations, they exact a proportionally higher health care cost than other hospitalizations.2,3 Approximately $8 billion is spent annually to provide medical and rehabilitative care for affected children in the United States.4,5 Thus, birth defects impart a significant burden to families and society.

First Page Preview View Large
First page PDF preview
First page PDF preview
×