To the Editor We read with interest the study by Wu et al1 recently published in JAMA Pediatrics, examining the effect of nebulized hypertonic saline vs normal saline administration in infants with bronchiolitis. We commend the authors for undertaking a large randomized clinical trial to complement existing evidence of the decreasing length of stay with hypertonic saline use.2- 5 However, we have concerns regarding the study analysis and interpretation and believe cautious interpretation of the findings is warranted.
Heaton VL, Tan NBL, Marco L. Nebulized Hypertonic Saline for Bronchiolitis. JAMA Pediatr. 2014;168(11):1077-1078. doi:10.1001/jamapediatrics.2014.1698