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Comment & Response
June 2015

Preeclampsia, Placental Insufficiency, Autism, and Antiphospholipid Antibodies

Author Affiliations
  • 1Department of Obstetrics and Gynecology, Assistance Publique-Hôpitaux de Paris, Hôpital Jean Verdier, Paris, France
  • 2Department of Pediatrics, Assistance Publique-Hôpitaux de Paris, Hôpital Jean Verdier, Paris, France
  • 3Department of Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hôpital Saint Antoine, Paris, France
JAMA Pediatr. 2015;169(6):605-606. doi:10.1001/jamapediatrics.2015.0349

To the Editor Walker et al1 published data from the Childhood Autism Risks from Genetics and Environment study in JAMA Pediatrics and concluded that fetal exposure to preeclampsia was significantly associated with autism spectrum disorder and developmental delay in children, particularly in severe presentations that involved placental insufficiency. Walker et al1 evoked a possible etiologic role for heightened maternal systemic inflammation, especially in association with maternal metabolic dysregulation, maternal infections, or autoimmune diseases.

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