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To the Editor Walker et al1 published data from the Childhood Autism Risks from Genetics and Environment study in JAMA Pediatrics and concluded that fetal exposure to preeclampsia was significantly associated with autism spectrum disorder and developmental delay in children, particularly in severe presentations that involved placental insufficiency. Walker et al1 evoked a possible etiologic role for heightened maternal systemic inflammation, especially in association with maternal metabolic dysregulation, maternal infections, or autoimmune diseases.
Carbillon L, Lachassinne E, Mekinian A. Preeclampsia, Placental Insufficiency, Autism, and Antiphospholipid Antibodies. JAMA Pediatr. 2015;169(6):605-606. doi:10.1001/jamapediatrics.2015.0349