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Comment & Response
June 2015

Preeclampsia, Placental Insufficiency, Autism, and Antiphospholipid Antibodies—Reply

Author Affiliations
  • 1Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of California, Davis
  • 2Medical Investigation of Neurodevelopmental Disorders Institute, University of California, Davis
  • 3Department of Medical Microbiology and Immunology, University of California, Davis
  • 4Department of Public Health Sciences, School of Medicine, University of California, Davis
JAMA Pediatr. 2015;169(6):606-607. doi:10.1001/jamapediatrics.2015.0345

In Reply Carbillon et al suggested that antiphospholipid antibodies (aPLs) in the mother and/or child might confound our findings from the CHARGE (Childhood Autism Risks from Genetics and Environment) case-control study published in JAMA Pediatrics that preeclampsia, particularly severe disease with placental insufficiency, was associated with autism spectrum disorder and developmental delay.1 We hypothesized a role for suboptimal placentation to explain our findings. Poor placentation resulting from defective endovascular decidual trophoblastic invasion is a central mechanism in mothers with antiphospholipid syndrome (APS).

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