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Comment & Response
November 2015

Breastfeeding and Childhood Leukemia IncidenceDuplicate Data Inadvertently Included in the Meta-analysis and Consideration of Possible Confounders

Author Affiliations
  • 1Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee
  • 2Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
JAMA Pediatr. 2015;169(11):1070. doi:10.1001/jamapediatrics.2015.2640

To the Editor We read with interest the recent meta-analysis by Amitay and Keinan-Boker1 about breastfeeding and childhood leukemia incidence. The authors identified published case-control studies and reported an inverse association for breastfeeding for 6 months or more compared with breastfeeding for less than 6 months (summary odds ratio [OR] = 0.81; 95% CL: 0.73, 0.89).1 Nonetheless, we describe herein the effect of unmeasured confounding as an alternate explanation for the observed association.

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