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Research Letter
March 2016

Resource Burden During the 2014 Enterovirus D68 Respiratory Disease Outbreak at Children’s Hospital ColoradoAn Unexpected Strain

Author Affiliations
  • 1Section of Hospital Medicine, Children’s Hospital Colorado, University of Colorado, Aurora
  • 2Department of Pediatrics, Children’s Hospital Colorado, University of Colorado, Aurora
  • 3Section of Infectious Diseases, Children’s Hospital Colorado, University of Colorado, Aurora
  • 4Section of Pulmonary Medicine, Children’s Hospital Colorado, University of Colorado, Aurora
  • 5Department of Epidemiology, Children’s Hospital Colorado, University of Colorado, Aurora
JAMA Pediatr. 2016;170(3):294-297. doi:10.1001/jamapediatrics.2015.3879

Enterovirus D68 (EV-D68) is a unique enterovirus that shares biological properties with human rhinoviruses.1 It primarily causes respiratory disease, particularly in children with asthma. Although rarely reported from 1970 to 2005, small clusters of EV-D68 respiratory disease have been increasingly reported since 2008.2,3 From August to November 2014, an outbreak of EV-D68 respiratory disease occurred throughout the United States, with 1153 microbiologically confirmed infections in 49 states.4,5 However, owing to marked underascertainment of cases, the true magnitude and impact of this outbreak are difficult to estimate. The objective of this study is to characterize and quantify the resource burden at a tertiary care children’s hospital during the 2014 EV-D68 respiratory disease outbreak.

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