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Editorial
March 2016

Examining the Evidence for Using Synbiotics to Treat or Prevent Atopic Dermatitis

Author Affiliations
  • 1Department of Allergy and Immune Disorders, Murdoch Childrens Research Institute, Parkville, Australia
  • 2Department of Paediatrics, University of Melbourne, Melbourne, Australia
  • 3Department of Allergy and Immunology, The Royal Children’s Hospital Melbourne, Parkville, Australia
  • 4Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia
JAMA Pediatr. 2016;170(3):201-203. doi:10.1001/jamapediatrics.2015.4406

Allergic diseases, such as atopic dermatitis (AD), food allergy, asthma, and allergic rhinitis, and other noncommunicable diseases share a common underlying pathogenesis involving aberrant chronic inflammation that results from dysregulation of immune response patterns, which are established in early life.1 The infant intestinal microbiota plays a critical role in programming of healthy vs dysregulated immune response patterns and is shaped by microbial exposures and diet in the pregnant mother and during the infant’s first years.2

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