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Original Investigation
June 2016

Recovery Curves for Pediatric Burn SurvivorsAdvances in Patient-Oriented Outcomes

Author Affiliations
  • 1Department of Health Law, Policy and Management, Center for the Assessment of Pharmaceutical Practices, Boston University School of Public Health, Boston, Massachusetts
  • 2Department of Mathematical Sciences, Bentley University, Waltham, Massachusetts
  • 3School of Insurance and Economics, University of International Business and Economics, Beijing, China
  • 4Department of Surgery, Massachusetts General Hospital, Boston
  • 5Shriners Hospitals for Children, Galveston, Texas
  • 6Massachusetts Veterans Epidemiology Research and Information Center, Boston
  • 7Shriners Hospitals for Children, Boston, Massachusetts
  • 8Shriners Hospitals for Children, Cincinnati, Ohio
  • 9Shriners Hospitals for Children, Sacramento, California
  • 10Nebraska Medical Center, Omaha
  • 11Department of Pediatrics, College of Medicine–Jacksonville, University of Florida, Jacksonville
  • 12Kennedy Krieger Institute, Baltimore, Maryland
  • 13Children’s Hospital of Michigan, Detroit
  • 14North Carolina Jaycee Burn Center, Chapel Hill
  • 15Harvard Medical School, Boston, Massachusetts
  • 16Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Pediatr. 2016;170(6):534-542. doi:10.1001/jamapediatrics.2015.4722

Importance  Patient-reported outcomes serving as benchmarks for recovery of pediatric burn survivors are lacking, and new approaches using longitudinal cohorts for monitoring their expected recovery based on statistical models are needed for patient management during the early years following the burn.

Objective  To describe multidimensional patient-reported outcomes among pediatric burn survivors younger than 5 years to establish benchmarks using recovery curve methods.

Design, Setting, and Participants  Prospective cohort study of pediatric burn survivors younger than 5 years at 12 burn centers. Age-matched nonburned reference groups were studied to define expected results in normal growth and development. The Burn Outcomes Questionnaire for children aged 0 to 5 years (BOQ0-5) was administered to parents of children who had burns and were younger than 5 years. Mixed models were used to generate 48-month recovery curves for each of the 10 BOQ0-5 domains. The study was conducted between January 1999 and December 2008.

Main Outcomes and Measures  The 10 BOQ0-5 domains including play, language, fine motor skills, gross motor skills, emotional behavior, family functioning, pain/itching, appearance, satisfaction with care, and worry/concern up to 48 months after burn injury.

Results  A total of 336 pediatric burn survivors younger than 5 years (mean [SD] age, 2.0 [1.2] years; 58.4% male; 60.2% white, 18.6% black, and 12.0% Hispanic) and 285 age-matched nonburned controls (mean [SD] age, 2.4 [1.3] years; 51.1% male; 67.1% white, 8.9% black, and 15.0% Hispanic) completed the study. Predicted scores improved exponentially over time for 5 of the BOQ0-5 domains (predicted scores at 1 month vs 24 months: play, 48.6 vs 52.1 [P = .03]; language, 49.2 vs 54.4 [P < .001]; gross motor skills, 48.7 vs 53.0 [P = .002]; pain/itching, 15.8 vs 33.5 [P < .001]; and worry/concern, 31.6 vs 44.9 [P < .001]). Pediatric burn survivors had higher scores in language, emotional behavior, and family functioning domains compared with healthy children in later months.

Conclusions and Relevance  This study demonstrates significant deficits in multiple functional domains across pediatric burn survivors compared with controls. Recovery curves can be used to recognize deviation from the expected course and tailor care to patient needs.