[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.147.238.62. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 933
Citations 0
Original Investigation
Adolescent and Young Adult Health
May 2016

Childhood Psychosocial Factors and Coronary Artery Calcification in AdulthoodThe Cardiovascular Risk in Young Finns Study

Author Affiliations
  • 1Department of Medicine, University of Turku, Turku, Finland
  • 2Division of Medicine, Turku University Hospital, Turku, Finland
  • 3Murdoch Childrens Research Institute and Royal Children’s Hospital, Melbourne, Australia
  • 4Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland
  • 5Unit of Personality, Work and Health, Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
  • 6Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland
  • 7National Institute for Health and Welfare, Helsinki, Finland
  • 8The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
  • 9Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia
  • 10Department of Pediatrics, University of Melbourne, Melbourne, Australia
  • 11Monash University, Melbourne, Australia
  • 12Department of Medicine and Cardiology, University of Melbourne, Melbourne, Australia
  • 13The Institute of Clinical Medicine, University of Turku, Turku, Finland
  • 14Heart Center, Turku University Hospital, Turku, Finland
  • 15Division of Imaging, Turku University Hospital, Turku, Finland
  • 16Department of Pediatrics, University of Tampere, Tampere University Hospital, Tampere, Finland
  • 17Department of Clinical Physiology, University of Tampere, Tampere University Hospital, Tampere, Finland
  • 18Department of Radiology, University of Tampere, Tampere University Hospital, Tampere, Finland
  • 19Department of Clinical Physiology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
  • 20Department of Radiology, University of Eastern Finland, Kuopio and University Hospital, Kuopio, Finland
  • 21Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
JAMA Pediatr. 2016;170(5):466-472. doi:10.1001/jamapediatrics.2015.4121
Abstract

Importance  There is increasing evidence supporting the importance of psychosocial factors in the pathophysiology of atherosclerotic disease. They have been shown to be associated with the population attributable risk for myocardial infarction.

Objective  To determine if a score of favorable childhood psychosocial factors would be associated with decreased coronary artery calcification in adulthood.

Design, Setting, and Participants  The analyses were performed in 2015 using data gathered in 1980 and 2008 within the longitudinal Cardiovascular Risk in Young Finns Study. The data source consisted of 311 individuals who had psychosocial factors measured at ages 12 years to 18 years and coronary artery calcification measured 28 years later in adulthood. The summary measure of psychosocial factors in childhood comprised measures of socioeconomic factors, emotional factors, parental health behaviors, stressful events, self-regulation of the child, and social adjustment of the child.

Main Outcomes and Measures  Coronary artery calcification at ages 40 years to 46 years.

Results  Of the 311 participants, 48.2% were men. Of the participants, 55 (17.7%) had some calcium observed in their coronary arteries. A 1-SD increase in a favorable summary score of childhood psychological factors was associated with an adulthood coronary artery calcification probability of 0.85 (95% CI, 0.76-0.95) (P = .006). This inverse relationship remained significant after adjustment for age, sex, and conventional childhood risk factors (0.85; 95% CI, 0.74-0.97; P = .02) or for age, sex, adulthood conventional cardiovascular risk factors, socioeconomic status, social support, and depressive symptoms (0.83; 95% CI, 0.71-0.97; P = .02).

Conclusions and Relevance  In this longitudinal study, we observed an independent association between childhood psychosocial well-being and reduced coronary artery calcification in adulthood. A positive childhood psychosocial environment may decrease cardiovascular risk in adulthood and may represent a potentially modifiable risk determinant.

×