To the Editor The results of the report by Chang et al,1 demonstrating that melatonin supplementation is associated with improved sleep-onset latency and disease severity in children with atopic dermatitis, may provide further insight into the phenomenon of nocturnal peripheral vasodilatation. It is suggested that nocturnal peripheral vasodilatation provides a thermal afferent stimulus emanating from the cutaneous warm sensors to the sleep center, which contributes to the initiation of sleep onset in humans.2,3 The increased heat loss induced by the peripheral vasodilatation causes the decrease in deep body temperature during the night.
Mekjavic IB, Macdonald IA. Melatonin-Induced Nocturnal Vasodilatation Contributes to Skin Regeneration. JAMA Pediatr. 2016;170(6):621-622. doi:10.1001/jamapediatrics.2016.0131