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Comment & Response
June 2016

Melatonin-Induced Nocturnal Vasodilatation Contributes to Skin Regeneration

Author Affiliations
  • 1Department of Automation, Biocybernetics, and Robotics, Jozef Stefan Instititute, Ljubljana, Slovenia
  • 2Medical Research Council and Arthritis Research UK, Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham Medical School, Nottingham, England
JAMA Pediatr. 2016;170(6):621-622. doi:10.1001/jamapediatrics.2016.0131

To the Editor The results of the report by Chang et al,1 demonstrating that melatonin supplementation is associated with improved sleep-onset latency and disease severity in children with atopic dermatitis, may provide further insight into the phenomenon of nocturnal peripheral vasodilatation. It is suggested that nocturnal peripheral vasodilatation provides a thermal afferent stimulus emanating from the cutaneous warm sensors to the sleep center, which contributes to the initiation of sleep onset in humans.2,3 The increased heat loss induced by the peripheral vasodilatation causes the decrease in deep body temperature during the night.

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