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Comment & Response
June 2016

Melatonin-Induced Nocturnal Vasodilatation Contributes to Skin Regeneration–Reply

Author Affiliations
  • 1Department of Pediatrics, Taipei City Hospital Renai Branch, Taipei, Taiwan
  • 2Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
  • 3National Yang-Ming University, Taipei, Taiwan
  • 4Department of Pediatrics, National Taiwan University Children’s Hospital, Taipei, Taiwan
  • 5Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
  • 6Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
JAMA Pediatr. 2016;170(6):622. doi:10.1001/jamapediatrics.2016.0138

In Reply We thank Mekjavic and Macdonald for providing their insightful comments and theory that peripheral vasodilation might be involved in the mechanism of how melatonin helps improve disease severity in children with atopic dermatitis. Temperature and the circadian rhythm have been found to have much influence on the immune system. Cytokine production is rhythmic, and immune responses differ at different body temperatures and at different times of the day.13 Therefore, it is reasonable to hypothesize that these factors play important roles in the effect of melatonin on atopic dermatitis. However, we did not measure peripheral blood flow or body temperature in our study. Therefore, our study cannot provide enough evidence to prove this theory, but this would be an interesting direction for future studies.

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