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Comment & Response
June 2016

Does Metformin Really Increase Height or Is There Some Problem With the Controls?

Author Affiliations
  • 1The University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
JAMA Pediatr. 2016;170(6):620-621. doi:10.1001/jamapediatrics.2015.4962

To the Editor I read with interest the meta-analysis by Kuzik et al.1 This study included 10 randomized clinical studies investigating the effects of metformin on height, weight, and body mass index. Meta-analysis of the 5 studies with the highest cumulative dose revealed a rather surprising outcome that the authors described as a “dose-response relationship between metformin use and increases in height.”1 They did not offer any clear hypothesis to explain this finding. In their article, the 2 studies with the greatest contribution to the positive significance of this finding are Kendall et al2 (1-cm difference; weight, 37.3%) and Ibáñez et al3 (3.8-cm difference; weight, 16.7%).

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