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Research Letter
July 2016

Expression of Circulating Muscarinic Receptors in Infants With Severe Idiopathic Life-Threatening Events

Author Affiliations
  • 1Unit of Cardiopediatrics, Hautepierre University Hospital, Strasbourg, France
  • 2Laboratory of Neurobiology and Cardiovascular Pharmacology, Federation of Translational Medicine, University of Strasbourg, Strasbourg, France
  • 3Center of Clinical Investigation, University Hospitals of Strasbourg, Strasbourg, France
JAMA Pediatr. 2016;170(7):707-708. doi:10.1001/jamapediatrics.2015.4762

About half of the apparent life-threatening events (ALTEs) that occur among infants remain unexplained and are called idiopathic.1 Yet there is no biomarker associated with idiopathic ALTEs. Although the connection between ALTEs and sudden infant death syndrome (SIDS) remains controversial, the cholinergic system has been investigated in the pathogenesis of both.24 We investigate the M2 muscarinic receptors’ expression in the blood samples of infants who experienced severe ALTEs.

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