About half of the apparent life-threatening events (ALTEs) that occur among infants remain unexplained and are called idiopathic.1 Yet there is no biomarker associated with idiopathic ALTEs. Although the connection between ALTEs and sudden infant death syndrome (SIDS) remains controversial, the cholinergic system has been investigated in the pathogenesis of both.2- 4 We investigate the M2 muscarinic receptors’ expression in the blood samples of infants who experienced severe ALTEs.
Adamopoulos C, Greney H, Beutelstetter M, Bousquet P, Livolsi A. Expression of Circulating Muscarinic Receptors in Infants With Severe Idiopathic Life-Threatening Events. JAMA Pediatr. 2016;170(7):707-708. doi:10.1001/jamapediatrics.2015.4762