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Comment & Response
July 2016

Prenatal Antidepressant Use and Risk of Autism Spectrum Disorders in Children

Author Affiliations
  • 1Clinical Pharmacy Specialist, Oncology, Hillcrest Hospital, Cleveland Clinic, Mayfield Heights, Ohio
  • 2Clinical Pharmacy Specialist, Obstetrics, Neonatology and Pediatrics. Hillcrest Hospital, Cleveland Clinic, Mayfield Heights, Ohio
JAMA Pediatr. 2016;170(7):713-714. doi:10.1001/jamapediatrics.2016.0736

To the Editor Boukhris et al1 reported a potentially significant correlation between in utero antidepressant (AD) exposure and diagnosis of autism spectrum disorder (ASD) in children; specifically after maternal use of selective serotonin reuptake inhibitors in the second and/or third trimester. At the very least, the research depicts a potential trend to the linkage of ASD with in utero exposure to ADs, which has previously been reported in the medical literature.2,3 However, an unclear explanation of study design and inconsistencies in the reported data in this article suggest that one should interpret the authors’ results with caution.

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