To the Editor We read with great interest the article “Genetic Differential Susceptibility to Socioeconomic Status and Childhood Obesogenic Behavior: Why Targeted Prevention May Be the Best Societal Investment,” by Silveira et al.1 In this study, the authors found that girls carrying the 7-repeat allele of DRD4 who were from a low-income bracket had increased fat intake compared with noncarriers. Similarly, girls carrying the 7-repeat allele of DRD4 who were from families with a higher income bracket had decreased fat intake compared with noncarriers. The authors postulated that the 7-repeat allele of DRD4 might not simply indicate increased susceptibility to obesity but actually be a plasticity allele that might be advantageous in more favorable settings but obesogenic in adversity.
Yeo V, Poulton A, Ashokan A. DRD4, Income, and Children’s Food ChoicesPlasticity Allele or Different Opportunities?. JAMA Pediatr. 2016;170(8):810. doi:10.1001/jamapediatrics.2016.1040