In Reply We thank Dr Pagliari for her interest in our study. We agree that sociodemographic factors are inextricably linked to both asthma and obesity and that deprivation represents a common root cause for both conditions. Evidence also suggests that pediatric obesity may be an independent risk factor for asthma through several mechanisms including metabolic dysregulation, chronic inflammation, and mechanical effects of central adiposity.1 Our Canadian Healthy Infant Longitudinal Development (CHILD) cohort2 is poised to make important contributions to this literature because we have prospectively collected anthropometric and lung function measurements from birth through early childhood, and we are currently performing clinical assessments including standardized asthma diagnosis for all children as they reach 5 years of age.
Azad MB, de Souza RJ, Sharma AK. Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index—Reply. JAMA Pediatr. 2016;170(11):1117-1119. doi:10.1001/jamapediatrics.2016.2822