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Comment & Response
November 2016

Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index—Reply

Author Affiliations
  • 1Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
  • 2Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada
  • 3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
  • 4Department of Nutritional Sciences, University of Toronto and Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada
  • 5George and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada
JAMA Pediatr. 2016;170(11):1117-1119. doi:10.1001/jamapediatrics.2016.2822

In Reply We thank Dr Pagliari for her interest in our study. We agree that sociodemographic factors are inextricably linked to both asthma and obesity and that deprivation represents a common root cause for both conditions. Evidence also suggests that pediatric obesity may be an independent risk factor for asthma through several mechanisms including metabolic dysregulation, chronic inflammation, and mechanical effects of central adiposity.1 Our Canadian Healthy Infant Longitudinal Development (CHILD) cohort2 is poised to make important contributions to this literature because we have prospectively collected anthropometric and lung function measurements from birth through early childhood, and we are currently performing clinical assessments including standardized asthma diagnosis for all children as they reach 5 years of age.

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