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Comment & Response
December 2016

Modeling the Effects of Priming With the Whole-Cell Bordetella Pertussis Vaccine—Reply

Author Affiliations
  • 1New Mexico State University, Las Cruces
  • 2Santa Fe Institute, Santa Fe, New Mexico
  • 3University of Vermont, Burlington
  • 4Institute for Disease Modeling, Bellevue, Washington
  • 5University of Washington, Seattle
JAMA Pediatr. 2016;170(12):1229. doi:10.1001/jamapediatrics.2016.2819

In Reply We agree with Snelling and McIntyre that our model, like all models, relies on several assumptions. However, we believe the explicit underlying assumption that an initial dose of the whole-cell pertussis (wP) vaccine followed by the standard course of acellular pertussis vaccination blocks asymptomatic infection is supported by rigorous clinical evidence (studies by Liko et al,1 Witt et al,2 and Sheridan et al,3 as cited in our original study).4

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