Incidence rates for neonatal abstinence syndrome (NAS) and maternal opioid use increased nearly 5-fold in the United States between 2000 and 2012.1 Previous studies suggest the incidence of NAS may be increasing rapidly in some rural states,2 in parallel with rising rural rates of other opioid use–related conditions including hepatitis C and overdose deaths.3,4 To our knowledge, no study has examined national trends in NAS and maternal opioid use among rural patients compared with their urban counterparts.
Villapiano NLG, Winkelman TNA, Kozhimannil KB, Davis MM, Patrick SW. Rural and Urban Differences in Neonatal Abstinence Syndrome and Maternal Opioid Use, 2004 to 2013. JAMA Pediatr. Published online December 12, 2016. doi:10.1001/jamapediatrics.2016.3750