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Comment & Response
June 26, 2017

Venous vs Arterial Lactate and 30-Day Mortality in Pediatric Sepsis—Reply

Author Affiliations
  • 1Department of Pediatrics, University of Colorado School of Medicine, Aurora
  • 2Section of Pediatric Emergency Medicine, Children’s Hospital Colorado, Aurora
  • 3Adult and Child Center for Outcomes Research and Delivery Science, University of Colorado, Aurora
JAMA Pediatr. Published online June 26, 2017. doi:10.1001/jamapediatrics.2017.1601

In Reply We thank Schlapbach et al for their letter and their analyses showing the comparability of the association between venous and arterial lactate and odds of mortality in children critically ill with infection.

Both their study of 4403 children with invasive infections in intensive care units in Australia and New Zealand and our study of 1299 children with clinically suspected sepsis in an emergency department in the United States demonstrated an association between early lactate levels and mortality.1,2 As 2 of the largest cohorts evaluating the question of first-hours lactate in pediatric sepsis to our knowledge, similar conclusions were reached in our study, entirely using venous lactate, and their study including both arterial and venous lactate measurements. The additional analyses included in their letter serve as important confirmation that arterial and venous lactate are similarly associated with mortality.

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